AI Agents for Maternal Mental Health

Every year, 1 in 5 mothers
silently struggles

Perinatal Mood and Anxiety Disorders (PMADs) are the #1 complication of pregnancy — yet most go undiagnosed and untreated. Nyx Health is changing that.

21%
Perinatal Women Affected
$14.2B
Annual Societal Cost in the US
<25%
Receive Adequate Treatment
Explore the data
The Problem

PMADs are the #1 complication of pregnancy

Affecting more than 1 in 5 pregnant and postpartum women, Perinatal Mood and Anxiety Disorders represent a hidden epidemic — one that carries severe consequences for both mother and child when left untreated.

  • 🧠
    Maternal Mental & Physical Health PMADs have already become the leading cause of maternal morbidity and mortality in the United States.
  • 📉
    Massive Underdiagnosis and Untreated Despite being common, fewer than half of affected women are ever screened or identified.
  • 🤱
    Two Lives at Stake Untreated PMADs affect child cognitive, developmental, and emotional outcomes for years.
Prevalence
1 in 5 Pregnant & Postpartum Women
Each figure represents 20% of the population.
Treatment Gap

The Treatment Cascade

Tracing the journey from prevalence to remission reveals a system that loses patients at every step. Both Antenatal Depression (AND) and Postpartum Depression (PPD) show alarming drop-offs before adequate care is reached.

Flow Diagram
Antenatal & Postpartum Depression — From Prevalence to Remission
Hover over the flows to see exact percentages at each stage.
Cost of Inaction

$14.2 billion in annual societal costs

Untreated PMADs generate enormous economic burden — spanning maternal healthcare, child outcomes, and lost productivity. This cost is largely preventable.

Total Annual Burden
$14.2B
Societal cost of untreated PMADs per birth cohort in the United States (2017).
Source: Luca et al., 2020
Distribution
Maternal vs. Child Cost Breakdown
Hover to reveal cost details by group.
Per-Case Economic Burden
$35,500/Dyad
Lifetime economic cost per mother-child pair (dyad) when PMADs go untreated (2017).
Source: Luca et al., 2020
Maternal Burden
Maternal Costs of Untreated PMADs
Bubble size = relative cost ($ millions). Hover for details.
Child Burden
Child Costs of Untreated PMADs
Bubble size = relative cost ($ millions). Hover for details.
Systemic Disparity

A crisis that disproportionately
impacts Black mothers

US maternal mortality has worsened for decades — and the racial gap is stark. Black women face mortality rates 2–3× higher than white women, and the US trails far behind peer nations globally.

⚠️

Black women in the US die at 2–3× the rate of white women

Structural racism, implicit bias in clinical settings, and barriers to mental health access drive this preventable disparity. AI-powered tools must be built with equity at their core.

1998–2020 Trend
US Maternal Mortality Rate by Race
Deaths per 100,000 live births. Lines animate on load. Hover to highlight.
Global Comparison
Maternal Mortality in High-Income Countries
The US consistently ranks last among peer nations. Hover for country details.
Join Us

AI can close the gap.
Let's build it together.

Nyx Health is building the next generation of AI-powered tools for early PMAD detection, continuous monitoring, and personalized intervention. We're looking for partners, clinicians, and investors.

Get in Touch